General Information

Product

CC2D1A Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 850-900 on human Coiled-coil and C2 domain-containing protein 1A protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q6P1N0

Overview

Transcription factor that binds specifically to the DRE (dual repressor element) and represses HTR1A gene transcription in neuronal cells. The combination of calcium and ATP specifically inactivates the binding with FRE. May play a role in the altered regulation of HTR1A associated with anxiety and major depression. Mediates HDAC-independent repression of HTR1A promoter in neuronal cell. Performs essential function in controlling functional maturation of synapses. Plays distinct roles depending on its localization. When cytoplasmic, acts as a scaffold protein in the PI3K/PDK1/AKT pathway. Repressor of HTR1A when nuclear. In the centrosome, regulates spindle pole localization of the cohesin subunit SCC1/RAD21, thereby mediating centriole cohesion during mitosis.

Molecular Function

cadherin binding

RNA polymerase II proximal promoter sequence-specific DNA binding

RNA polymerase II transcription factor activity, sequence-specific DNA binding

signal transducer activity

transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding

Subcellular Location

Nucleus, centrosome, cytoplasm

Structure

Belongs to the CC2D1 family.

Alternative Nomenclature

Akt kinase interacting protein 1 antibody

Coiled coil and C2 domain containing protein 1A antibody

Five repressor element under dual repression binding protein 1 antibody

FRE under dual repression binding protein 1 antibody

FREUD 1 antibody

Freud 1/Aki1 antibody

Mental retardation, nonsyndromic, autosomal recessive, 3 antibody

MRT3 antibody

Putative NF kappa B activating protein 023N antibody