General Information

Product

Angiopoietin-like 4 Antibody

Description

Affinity Purified Angiopoietin-related protein 4 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse

Immunogen

Synthetic peptide taken within amino acid region 50-100 on mouse Angiopoietin-related protein 4.

Accession #

NCBI: NP_065606.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q9Z1P8

Overview

Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity (By similarity). In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.

Molecular Function

enzyme inhibitor activity

identical protein binding

Subcellular Location

Secreted

Expression

Predominantly expressed in adipose tissue and is strongly up-regulated by fasting in white adipose tissue and liver.

Structure

Coiled coil, Signal

Alternative Nomenclature

Angiopoietin like 4 antibody

Angiopoietin-like protein 4 antibody

ANGPT L2 antibody

ANGPT L4 antibody

Angptl4 antibody

ARP4 antibody

Fasting induced adipose factor antibody

FIAF antibody

HARP antibody

Hepatic angiopoietin related protein antibody

Hepatic fibrinogen/angiopoietin-related protein antibody

HFARP antibody

NL2 antibody

Peroxisome proliferator-activated receptor (PPAR) gamma induced angiopoietin related protein antibody

PGAR antibody

pp1158 antibody

PPARG angiopoietin related protein antibody

PSEC0166 antibody

TGQTL antibody

UNQ171 antibody

Weakly similar to angiopoietin 1 [H.sapiens] antibody