General Information

Product

Aurora B Antibody

Description

Aurora Kinase B Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 300-344 on human Aurora Kinase B protein.

Accession #

NCBI: NP_004208.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q96GD4

Overview

Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Involved in the bipolar attachment of spindle microtubules to kinetochores and is a key regulator for the onset of cytokinesis during mitosis.

Molecular Function

ATP binding

histone serine kinase activity

kinase binding

metal ion binding

protein serine/threonine/tyrosine kinase activity

protein serine/threonine kinase activity

Subcellular Location

Spindle, Nucleus

Expression

High level expression seen in the thymus. It is also expressed in the spleen, lung, testis, colon, placenta and fetal liver. Expressed during S and G2/M phase and expression is up-regulated in cancer cells during M phase.

Structure

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.

Alternative Nomenclature

AIK2 antibody

AIM1 antibody

ARK2 antibody

AurB antibody

AURKB antibody

Aurora 1 antibody

Aurora and Ipl1 like midbody associated protein 1 antibody

Aurora kinase B antibody

Aurora related kinase 2 antibody

Aurora- and Ipl1-like midbody-associated protein 1 antibody

Aurora-B antibody

Aurora/IPL1 related kinase 2 antibody

IPL1 antibody

PPP1R48 antibody

Protein phosphatase 1 regulatory subunit 48 antibody

Serine/threonine-protein kinase 12 antibody

Serine/threonine-protein kinase aurora-B antibody

STK1 antibody

STK12 antibody

STK5 antibody