General Information

Product

Indoleamine 2, 3-dioxygenase 2 Antibody

Description

Affinity Purified Indoleamine 2,3-dioxygenase 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 370-420 on human Indoleamine 2,3-dioxygenase 2 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

Q6ZQW0

Overview

Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance.

Molecular Function

heme binding

indoleamine 2,3-dioxygenase activity

metal ion binding

tryptophan 2,3-dioxygenase activity

Subcellular Location

cytosol

Expression

Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%).

Structure

Belongs to the indoleamine 2,3-dioxygenase family.

Alternative Nomenclature

3-dioxygenase antibody

I23O1_HUMAN antibody

IDO 2 antibody

IDO antibody

IDO-2 antibody

IDO2 antibody

INDO antibody

indolamine 2,3 dioxygenase antibody

Indole 2 3 dioxygenase antibody

indoleamine 2 3 dioxygenase 1 antibody

indoleamine 2 3 dioxygenase antibody

Indoleamine 2,3-dioxygenase 1 antibody

Indoleamine pyrrole 2 3 dioxygenase antibody

Indoleamine-pyrrole 2 antibody