General Information

Product

DYRK1 Antibody

Description

Affinity Purified Dual specificity tyrosine-phosphorylation-regulated kinase 1A Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-350 on human Dual specificity tyrosine-phosphorylation-regulated kinase 1A.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q13627

Overview

May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Modulates alternative splicing by phosphorylating the splice factor SRSF6. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1, SRSF6 and SIRT1. Exhibits a sugstrate preference for proline at position P+1 and arginine at position P-3.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Nucleus speckle

Expression

Ubiquitous. Highest levels in skeletal muscle, testis, fetal lung and fetal kidney.

Structure

The polyhistidine repeats act as targeting signals to nuclear speckles.

Alternative Nomenclature

Dual specificity tyrosine phosphorylation regulated kinase Dual specificity YAK1-related kinase DYRK DYRK1 DYRKA hMNB HP86 Minibrain, Drosophila, homolog of MNB MNB protein kinase Mnb protein kinase homolog hp86 MNB protein kinase, Serine/threonine-specific MNB/DYRK protein kinase MNBH MRD7 Protein kinase minibrain homolog Serine/threonine kinase MNB