General Information

Product

FBXW4 / SHFM3 Antibody Affinity Purified

Description

Affinity Purified F-box and WD-40 domain protein 4 Antibody

Verified Applications

DB, ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 240-290 on human FBX4 protein.

Accession #

GenBank: AAH07380.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.68-0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P57775

Overview

Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Likely to be involved in key signaling pathways crucial for normal limb development. May participate in Wnt signaling.

Molecular Function

Developmental Protein

Subcellular Location

Ubiquitin ligase complex

Expression

Expressed in brain, kidney, lung and liver.

Structure

Part of a SCF (SKP1-cullin-F-box) protein ligase complex

Alternative Nomenclature

DAC antibody

Dactylin antibody

F box and WD 40 domain containing protein 4 antibody

F box/WD repeat protein 4 antibody

F-box/WD repeat-containing protein 4 antibody

FBW 4 antibody

FBWD4 antibody

SHFM 3 antibody

SHSF3 antibody

Split hand/foot malformation (ectrodactyly) type antibody