General Information

Product

FOXO3 Antibody

Description

Affinity Purified Forkhead box protein O3 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 620-670 on human Forkhead box protein O3.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500. Apparent MW is 71 kDa.

Protein

Uniprot #

O43524

Overview

Transcriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5"-[AG]TAAA[TC]A-3". Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3"UTR of MYC transcript and prevent its translation.

Molecular Function

Activator

Subcellular Location

Cytoplasm, Nucleus

Expression

Ubiquitous

Structure

Contains 1 fork-head DNA-binding domain.

Alternative Nomenclature

AF6q21 antibody FKHR2 antibodyFKHRL 1 antibodyFKHRL1 antibody Forkhead box protein O3 antibodyForkhead box protein O3A antibodyForkhead Drosophila homolog of in rhabdomyosarcoma like 1 antibody Forkhead in rhabdomyosarcoma like 1 antibody FOX O3A antibodyFOXO2 antibodyfoxo3 antibody FOXO3A antibody