General Information

Product

RUNX3 Antibody Affinity Purified

Description

Affinity Purified Runt-related transcription factor 3 Antibody N-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-50 on human Runt-related transcription factor 3 protein.

Accession #

NCBI:  NP_001026850.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.53 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q13761

Overview

CBF binds to the core site, 5"-PYGPYGGT-3", of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters.

Molecular Function

ATP binding, RNA polymerase II regulatory region sequence-specific DNA binding

Subcellular Location

Nucleus, cytoplasm

Structure

Heterodimer of an alpha and a beta subunit. The alpha subunit binds DNA as a monomer and through the Runt domain. DNA-binding is increased by heterodimerization. Interacts with TLE1 and SUV39H1.

Alternative Nomenclature

Acute myeloid leukemia 2 protein antibody

AML2 antibody

CBF alpha 3 antibody

CBFA 3 antibody

Core binding factor alpha 3 subunit antibody

core binding factor antibody

Core binding factor runt domain alpha subunit 3 antibody

Core-binding factor subunit alpha-3 antibody

FLJ34510 antibody

MGC16070 antibody

Oncogene AML 2 antibody

PEA2 alpha C antibody

PEBP2 alpha C antibody

Pebp2a3 antibody

PEBP2aC antibody

Polyomavirus enhancer binding protein 2 alpha C subunit antibody

runt domain alpha subunit 3 antibody

runt related transcription factor 3 antibody

RUNX 3 antibody

SL3 3 enhancer factor 1 alpha C subunit antibody

SL3/AKV core binding factor alpha C subunit antibody

Transcription factor AML2 antibody