General Information

Product

ZFP36L2 Antibody

Description

Affinity Purified Zinc finger protein 36, C3H1 type-like 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid reigon 350-400 on human Zinc finger protein 36, C3H1 type-like 2.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:150-1:500

Protein

Uniprot #

P47974

Overview

mRNA-binding protein that plays a key role in self-renewal of erythroid cells in response to glucocorticoids. Specifically binds to the AU-rich element (ARE) in the 3"-UTR of target mRNAs, promoting their deadenylation and degradation (PubMed:14981510). Specifically expressed in burst-forming unit-erythroid (BFU-E) progenitors in response to glucocorticoids and acts as a negative regulator of erythroid cell differentiation: promotes self-renewal of erythroid cells by binding mRNAs that are induced or highly expressed during terminal erythroid differentiation and promotes their degradation, preventing erythroid cell differentiation. Down-regulated during erythroid differentiation from the BFU-E stage, stabilizing mRNAs required for terminal differentiation.

Molecular Function

AU-rich element binding, DNA binding, metal ion binding, mRNA 3"-UTR AU-rich region binding, poly(A) RNA binding, transcription factor activity, sequence-specific DNA binding

Subcellular Location

Cytoplasm, Nucleus

Structure

Repeat, Zinc-finger

Alternative Nomenclature

BRF2 antibody

Butyrate response factor 2 antibody

C3H1 type-like 2 antibody

EGF response factor 2 antibody

ERF 2 antibody

Protein TIS11D antibody

RNF162C antibody

TIS11D antibody

ZFP36 like 2 antibody

ZFP36 ring finger protein like 2 antibody

Zinc finger protein 36 antibody

Zinc finger protein 36, C3H type like 1 antibody

zinc finger protein 36, C3H type like 2 antibody