General Information

Product

REST / NRSF Antibody Affinity Purified

Description

Affinity Purified RE1-silencing transcription factor Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1000-1097on human REST protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.52-0.54 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q13127

Overview

Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells. Restricts the expression of neuronal genes by associating with two distinct corepressors, mSin3 and CoREST, which in turn recruit histone deacetylase to the promoters of REST-regulated genes.

Molecular Function

Repressor, Chromatin binding, Core promoter binding

Subcellular Location

Nucleus

Expression

Ubiquitous, expressed at higher levels in the tissues of the lymphocytic compartment, including spleen, thymus, peripheral blood lymphocytes and ovaries.

Structure

Interacts with SIN3A, SIN3B and RCOR1. Interacts with CDYL.

Alternative Nomenclature

Neural Restrictive Silencer Factor antibody

NRSF antibody

RE1 silencing transcription factor antibody

Repressor binding to the X2 box antibody

REST antibody

X2 box repressor antibody

XBR antibody