General Information

Product

SOX2 Antibody

Description

Affinity Purified Sex determing region Y-box 2 Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Pig

Immunogen

Synthetic peptide taken within amino acid region 250-300on human Sex determining region Y-box 2 protein.

Accession #

GenBank: AJF45879.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

A0A0B5HSU3

Overview

Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity).

Molecular Function

Chromatin binding; DNA binding; miRNA binding; RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription

Subcellular Location

Nucleus

Structure

Interacts with ZSCAN10. Interacts with SOX3 and FGFR1.

Alternative Nomenclature

ANOP3 antibody

cb236 antibody

Delta EF2a antibody

lcc antibody

MCOPS3 antibody

MGC148683 antibody

MGC2413 antibody

RGD1565646 antibody

SRY (sex determining region Y) box 2 antibody

SRY box containing gene 2 antibody

SRY related HMG box gene 2 antibody

SRY-box 2 antibody

Transcription factor SOX 2 antibody

ysb antibody