General Information

Product

LARP7 Antibody Affinity Purified

Description

Affinity Purified LARP7 protein Antibody N-epitope

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 300-350 on human LARP7 protein.

Accession #

GenBank: AAI07710.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:4,000

ELISA

1:4,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q4G0J3

Overview

Negative transcriptional regulator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.

Molecular Function

RNA-binding; RNA processing

Subcellular Location

Nucleus

Structure

Integral part of the 7SK RNP complex. Specifically binds to the highly conserved 3"-terminal U-rich stretch of 7SK RNA. On stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex.

Alternative Nomenclature

HDCMA18P antibody

La related protein 7 antibody

La ribonucleoprotein domain family member 7 antibody

P TEFb interaction protein for 7SK stability antibody

PIP7S antibody