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当前位置: 首页 > 产品中心 > Functional_antibody > FabGennix/MERTK Antibody/MKT-101AP
商品详细FabGennix/MERTK Antibody/MKT-101AP
FabGennix/MERTK Antibody/MKT-101AP
FabGennix/MERTK Antibody/MKT-101AP
商品编号: MKT-101AP
品牌: FabGennix Inc
市场价: ¥7000.00
美元价: 3150.00
产地: 美国(厂家直采)
公司:
产品分类: 功能性抗体
公司分类: Functional_antibody
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍
  • Description
  • Publications
  • Specification Sheet

General Information

Product

MERTK Antibody

Description

Affinity Purified Human cellular proto-oncogene (c-mer) mRNA Antibody C-epitope

Verified Applications

CM, ELISA, Flow Cytometry,ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 900-994 on MerTK protein.

Accession #

NCBI: NP_075232

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:750-1:2,000

Protein

Uniprot #

P57097

Overview

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Molecular Function

Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Membrane; Single-pass type I membrane protein

Expression

Is expressed in many neoplastic B- and T-cells. Is expressed highly in testis, ovary, prostate, lung and kidney and is expressed at low levels in the spleen, small intestine, colon and liver.

Structure

Interacts with TNK2 upon activation. Interacts with extracellular ligands LGALS3, TUB, TULP1, and GAS6.

Alternative Nomenclature

c MER antibody

c mer proto oncogene tyrosine kinase antibody

Eyk antibody

MER antibody

MER receptor tyrosine kinase antibody

MERK antibody

MERPEN antibody

Mertk antibody

MERTK c-mer proto-oncogene tyrosine kinase antibody

MGC133349 antibody

nmf12 antibody

Nyk antibody

Proto oncogene tyrosine protein kinase MER antibody

Proto-oncogene c-Mer antibody

Receptor tyrosine kinase MerTK antibody

RP38 antibody

STK kinase antibody

Tyrosine-protein kinase Mer antibody

Protein information supplied by UniProt

品牌介绍
苏州蚂蚁淘Fabgennix授权代理业务。Fabgennix授权代理, Fabgennix北京代理, Fabgennix华东代理,Fabgennix华北代理,Fabgennix华中代理,Fabgennix华南代理。 Fabgennix 我们提供高质量的研究工具,专家技术支持,相关的准确数据以及快速的全球运输。我们不断在我们的库存中添加新产品,包括一级和二级抗体,试剂,试剂盒,多肽和阳性对照。我们所有的抗体都在内部开发和表征。我们为我们的Single Source Antibodies™感到自豪。 部分产品的详细列表:Fabgennix授权代理 货号 产品 价格 FGI-1989 StripOBuffer Western Blot Stripping Buffer $150.00  HRP-1060 Rabbit Anti-Chicken IgG HRP $150.00 FGI-1943 SolObuffer Cell Lysis Kit $175.00 FGI-1963 DiluOBuffer - Antibody Dilution Buffer $185.00  HIL2-E96.1 Human IL-2 ELISA Kit $495.00