General Information

Product

Ephrin Receptor A7 Antibody

Description

Affinity Purified EPHA7Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding taken within amino acid region 500-550 on humanEphrin type-A receptor 7protein.

Accession #

NCBI: NP_004431

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q15375

Overview

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity.

Molecular Function

Developmental protein, Kinase, Receptor, Transferase, Tyrosine-protein kinase

Subcellular Location

Cell membrane, Single-pass type 1 membrane protein

Expression

Widely Expressed

Structure

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses. Interacts (via PDZ-binding motif) with GRIP1 and PICK.

Alternative Nomenclature

Cek 11

Developmental kinase 1

EBK

EHK3

EK11

Embryonic brain kinase

Eph homology kinase 3

Eph receptor A7

EPH-like kinase 11

EphA7

Ephrin type-A receptor 7

hEK11

MDK 1

Receptor protein tyrosine kinase HEK 11

Tyrosine protein kinase receptor EHK 3