General Information

Product

SIRT1 Antibody

Description

Affinity Purified NAD-dependent protein deacetylase sirtuin-1 isoform 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Chicken, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid 25-75 on rat Sirtuin 1 protein.

Accession #

NCBI: NP_062786.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.69-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q923E4

Overview

NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in coordination of several separated cellular functions such as cell cycle, response to DNA damage, metabolism, apoptosis and autphagy.

Subcellular Location

Nucleus, PML body, cytoplasm. (Nucleus: Recruited to the nuclear bodies via its interaction with the PML. Colocalized with APEX1 in nucleus. May be found in nucleolus, nuclear euchromatin, heterochromatin and inner membrane. Shuttles between nucleus and cytoplasm).

Expression

Widely expressed. Weakly expressed in liver and skeletal muscle.

Alternative Nomenclature

75SirT1 antibody

HST2, S. cerevisiae, homolog of antibody

NAD dependent deacetylase sirtuin 1 antibody

Regulatory protein SIR2 homolog 1 antibody

SIR2 like protein 1 antibody

SIR2, S.cerevisiae, homolog-like 1 antibody

SIR2ALPHA antibody

SIR2L1 antibody

SirtT1 75 kDa fragment antibody

Sirtuin type 1 antibody