General Information

Product

EAAT1 Antibody

Description

Affinity Purified Excitatory Amino Acid Transporter 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide corresponding to C terminal amino acids 480-543 of Mouse EAAT1 protein. The selected peptide was post-synthetically modified to achieve highest antigenicity before coupling to carrier protein using heterobifunctional cross linker for immunogen preparation.

Sequence:

KPYQLIAQDNEPEKPVADSETK

Accession #

NCBI: NP_683740.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.61 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P56564

Overview

Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

Molecular Function

high-affinity glutamate transmembrane transporter activity;sodium:dicarboxylate symporter activity

Subcellular Location

plasma membrane; cell surface; fibril;neuronal cell body

Expression

Purkinje cell layer in cerebellum,lung,spleen, skeletal muscle and testis.

Structure

Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A3 subfamily has a Transmembrane helix.

Alternative Nomenclature

EA6 antibody

EAAT1 antibody

Excitatory amino acid transporter 1 antibody

FLJ25094 antibody

GLAST antibody

Glial high affinity glutamate transporter antibody

glutamate/aspartate transporter, high affinity, sodium-dependent antibody

High affinity neuronal glutamate transporter antibody

Slc1a3 antibody

Sodium dependent glutamate/aspartate transporter antibody

Solute carrier family 1 member 3 antibody