General Information

Product

ABHD2 Antibody

Description

Affinity Purified a/b hydrolase II Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on mouse a/b hydrolase II protein.

Accession #

GenBank: AAQ12022.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9QXM0

Overview

Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Involved in acrosomal reaction (PubMed:26989199). May also play a role in smooth muscle cells migration.

Molecular Function

Hydrolase, Serine esterase

Subcellular Location

Cell membrane; Single-pass type II membrane protein

Cytoplasmic vesicle › secretory vesicle › acrosome membrane

Expression

Widely expressed with higher expression in testis. Expressed by vascular smooth muscle cells, non vascular smooth muscle cells and heart.

Structure

Signal-anchor, Transmembrane, Transmembrane helix

Alternative Nomenclature

abhydrolase domain containing 2 antibody

alpha/beta hydrolase domain containing protein 2 antibody

HS1 2 antibody

LABH2 antibody

Lung alpha/beta hydrolase 2 antibody

PHPS1 2 antibody

protein PHPS1-2 antibody