FabGennix/Phospho-PDE4A Antibody/PPD4-140AP-免疫在线蚂蚁淘旗下平台

商品详细FabGennix/Phospho-PDE4A Antibody/PPD4-140AP

FabGennix/Phospho-PDE4A Antibody/PPD4-140AP

商品编号： PPD4-140AP

品牌： FabGennix Inc

市场价： ¥7000.00

美元价： 3150.00

产地：美国(厂家直采)

公司：

产品分类：功能性抗体

公司分类： Functional_antibody

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Description
Publications
QA_1
Q&A

General Information
Product	Phospho-PDE4A Antibody
Description	Affinity Purified Phosphorylated Phosphodiesterase 4A(S140) Antibody
Verified Applications	ELISA, IP, WB
Host	Rabbit
Species Cross Reactivity	Human, Mouse, Rabbit, Rat
Immunogen	Synthetic peptide corresponding to PKA phosphorylation site on PDE4A long form enzymes. The peptide was synthesized with phosphorylated serine residue.
Specificity	This antibody detects all known long-form variants of PDE4A, including PDE4A4, PDE4A5, PDE4A8, PDE4Ax when phosphorylated at the PKA phosphorylation site. It will not cross-react with PDE4A phosphorylated at the ERK phosphorylation site. It does not cross-react with other members of the PDE family including PDE4B or PDE4D.
Notes	This antibody is ideal for studying phosphorylation dependent signal transduction research of PDE4 activation.
Physical Properties
Quantity	100 µg
Volume	200 µl
Concentration	0.57 µg/µl in antibody stabilization buffer
Form	Affinity Purified
Clonality	Polyclonal
Storage	-20⁰C for long term storage
Application Protocol
DB	1:10,000
ELISA	1:10,000
Immunoprecipitation	1:150
Western Blot	1:500
Protein
Overview	Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.
Molecular Function	Hydrolase, 3",5"-cyclic-AMP phosphodiesterase activity, cAMP binding
Subcellular Location	Apical cell membrane, Cytoplasm, Membrane
Expression	Expressed in colonic epithelial cells (at protein level). Widespread; most abundant in skeletal muscle. Isoform 6 is detected in brain. Isoform 8 is detected in brain, placenta, lung and kidney. Isoform 7 is detected in heart and skeletal muscle.
Structure	Homodimer for the long isoforms. Isoforms with truncated N-termini are monomeric. Isoform 3 is part of a ternary complex containing PRKAR2A, PRKAR2B and AKAP9. Interacts with PDE4DIP. Identified in a complex composed of RYR1, PDE4D, PKA, FKBP1A and protein phosphatase 1 (PP1).
Alternative Nomenclature	cAMP specific 3",5" cyclic phosphodiesterase 4D antibody DKFZp686M11213 antibody 5""-cyclic phosphodiesterase 4D antibody cAMP specific 3" 5" cyclic phosphodiesterase 4D antibody cAMP specific phosphodiesterase 4D antibody cAMP specific phosphodiesterase PDE4D6 antibody cAMP-specific 3"" antibody cyclic AMP phosphodiesterase antibody DPDE 3 antibody FLJ97311 antibody HSPDE4D antibody PDE 43 antibody Pde4d antibody PDE4DN2 antibody Phosphodiesterase 4D cAMP specific (dunce (Drosophila) homolog phosphodiesterase E3) antibody Phosphodiesterase 4D cAMP specific Phosphodiesterase E3 dunce homolog Drosophila antibody STRK 1 antibody STRK1 antibody

Protein information supplied by UniProt

Fabgennix Phospho-PDE4A PKAAntibody has been used in 1 Publication

Zhu, Bing, et al. "Activation and induction of cyclic AMP phosphodiesterase (PDE4) in Rat pulmonary microvascular endothelial cells." Biochemical pharmacology 68.3 (2004): 479-491. PMID15242814

Western Blot; Human

Publishing research using PPD4-140AP? Please let us know, we can cite the reference in this datasheet.

We are interesting in your item, PPD4-140AP and I notice the immunogen is unclear to know the phosphorylation site of PDE4A. So could you please provide me the detailed information about the immunogen sequence and let me know which phosphorylation site of PDE4A does it recognize?
1. The phospho-PDE4A antibody was directed to Serine 140 in the rat/mouse PDE4A5 variant. This site is conserved in other PDE4A long form variants too.

We are interesting in your item, PPD4-140AP and I notice the immunogen is unclear to know the phosphorylation site of PDE4A. So could you please provide me the detailed information about the immunogen sequence and let me know which phosphorylation site of PDE4A does it recognize?
1. The phospho-PDE4A antibody was directed to Serine 140 in the rat/mouse PDE4A5 variant. This site is conserved in other PDE4A long form variants too.

品牌介绍

苏州蚂蚁淘Fabgennix授权代理业务。Fabgennix授权代理， Fabgennix北京代理， Fabgennix华东代理，Fabgennix华北代理，Fabgennix华中代理，Fabgennix华南代理。 Fabgennix 我们提供高质量的研究工具，专家技术支持，相关的准确数据以及快速的全球运输。我们不断在我们的库存中添加新产品，包括一级和二级抗体，试剂，试剂盒，多肽和阳性对照。我们所有的抗体都在内部开发和表征。我们为我们的Single Source Antibodies™感到自豪。部分产品的详细列表：Fabgennix授权代理货号产品价格 FGI-1989 StripOBuffer Western Blot Stripping Buffer $150.00 HRP-1060 Rabbit Anti-Chicken IgG HRP $150.00 FGI-1943 SolObuffer Cell Lysis Kit $175.00 FGI-1963 DiluOBuffer - Antibody Dilution Buffer $185.00 HIL2-E96.1 Human IL-2 ELISA Kit $495.00