General Information

Product

Phospho-PDE10A Antibody

Description

Affinity Purified Phosphorylated Phosphodiesterase 10A Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Phosphorylated synthetic MAP common to all PDE10A variants. Taken within amino acid region 1-50 on human PDE10A protein.

Accession #

GenBank: AAD32596.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.7 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9Y233

Overview

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.

Molecular Function

Hydrolase, metal-ion binding, cGMP binding

Subcellular Location

Cytoplasm

Expression

Abundant in the putamen and caudate nucleus regions of brain and testis, moderately expressed in the thyroid gland, pituitary gland, thalamus and cerebellum.

Structure

Homodimer

Alternative Nomenclature

5""-cyclic phosphodiesterase 10A antibody

cAMP and cAMP inhibited cGMP 3"5" cyclic phosphodiesterase 10A antibody

FLJ11894 antibody

HSPDE10A antibody

PDE 10A antibody

Pde10a antibody

Phosphodiesterase 10A antibody