General Information

Product

SIGLEC10 Antibody

Description

Affinity Purified Sialic acid-binding Ig-like lectin 10 Antibody

Verified Applications

ELISA, IP,WB

Host

Rabbit

Species Cross Reactivity

Human, Rat

Immunogen

Synthetic peptide taken within amino acid region 650-697on human SIGLEC10 protein.

Accession #

NCBI: NP_149121.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.56-0.60 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q96LC7

Overview

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,3- or alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.

Molecular Function

carbohydrate binding

Subcellular Location

Isoform 1,2,3,4: cell membrane, single-pass type I membrane protein; isoform 5: secreted

Expression

Expressed by peripheral blood leukocytes (eosinophils, monocytes and a natural killer cell subpopulation). Isoform5 is found to be the most abundant isoform. Found in lymph node, lung, ovary and appendix. Isoform 1 is found at high levels and isoform 2 at lower levels in bone marrow, spleen and spinal chord. Isoform 2 is also found in brain. Isoform 4 is specifically found in natural killer cells.

Alternative Nomenclature

PRO940 antibody

sialic acid binding Ig like lectin 10 Ig like lectin 7 antibody

Sialic acid binding Immunoglobulin like lectin 10 antibody

SIGLEC 10 antibody

Siglec G antibody

Siglec-like protein 2 antibody

SIGLEC10 antibody

Siglecg antibody

SLG2 antibody