General Information

Product

RIPK5 Antibody Affinity Purified

Description

Affinity Purified Dual serine/threonine and tyrosine protein kinase Antibody

Verified Applications

ELISA, IMM, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 200-250 on human Dual serine/threonine and tyrosine protein kinase protein (RIPK5).

Accession #

GenBank: Q6XUX3.2

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q6XUX3

Overview

Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation. May induce both caspase-dependent apoptosis and caspase-independent cell death.

Molecular Function

ATP binding; Protein serine/threonine kinase activity; Protein tyrosine kinase activity; ATP-binding; Nucleotide-binding

Subcellular Location

Cell junction, Cell membrane, Cytoplasm, Membrane

Expression

Predominantly expressed in skeletal muscle and testis. Expressed in basolateral and apical membranes of all tubular epithelia. Expressed in thin ascending limb of the loop of Henle and the distal convoluted tubule. Expressed in all layers of transitional ureteric epithelium and in the ureteric smooth-muscle cells. Weakly expressed in heart, brain, placenta, kidney, pancreas, spleen, thymus, prostate, uterus, small intestine, white blood cells, stomach, spinal cord and adrenal gland. Is widely distributed in the CNS. Also detected in several tumor cell lines.

Structure

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Contains 1 protein kinase domain.

Alternative Nomenclature

DSTYK antibody

Dual serine/threonine and tyrosine protein kinase antibody

Dusty PK antibody

Dusty protein kinase antibody

HDCMD38P antibody

KIAA0472 antibody

Receptor interacting protein kinase 5 antibody

Receptor interacting serine/threonine protein kinase 5 antibody

RIP homologous kinase antibody

RIPK5 antibody

SgK496 antibody

Sugen kinase 496 antibody