General Information

Product

EFEMP1 Antibody

Description

Affinity Purified EGF-containing fibulin-like extracellular matrix protein 1 Antibody

Verified Applications

ELISA, IHC, IP,WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic cyclic peptide corresponding to N terminal amino acids 25-42 of Human EFEMP1, peptide was covalently modified.

Sequence:

TYTQCTDGYEWDPVRQQC

Accession #

NCBI: XP_005264262.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500. Predicted molecular weight 60 kDa

Protein

Uniprot #

UPI000387D485

Overview

Binds EGFR, the EGF receptor, inducing EGFR autophosphorylation and the activation of downstream signaling pathways. May play a role in cell adhesion and migration. May function as a negative regulator of chondrocyte differentiation. In the olfactory epithelium, it may regulate glial cell migration, differentiation and the ability of glial cells to support neuronal neurite outgrowth.

Molecular Function

Calcium

Subcellular Location

Secreted; Extracellular space

Expression

In the eye, associated with photoreceptor outer and inner segment regions, the nerve fiber layer, outer nuclear layer and inner and outer plexiform layers of the retina.

Structure

Interacts with ECM1. Interacts with TIMP3.

Alternative Nomenclature

DHRD antibody

Doyne honeycomb retinal degeneration antibody

DRAD antibody

EFEMP 1 antibody

Epidermal growth factor containing fibulin like extracellular matrix protein 1 antibody

FBLN3 antibody

Fibrillin like antibody

FIBULIN 3 antibody

FLJ35535 antibody

Heat shock 70 KD protein 1 antibody

MGC111353 antibody

MLVT antibody

T16 protein antibody