General Information

Product

CAMKII gamma Antibody

Description

Affinity Purified Calcium/calmodulin-dependent protein kinase type II subunit gamma isoform 3 Antibody N-epitope

Verified Applications

CM, DB, ELISA, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 350-400on human CAMKII gamma protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.8 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q13555

Overview

Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in sarcoplsamic reticulum Ca2+ transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca2+ transport and in fast-twitch muscle participates in the control of Ca2+ release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning.

Molecular Function

Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Sarcoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side

Expression

Skeletal muscle

Structure

CAMK2 is composed of 4 different chains: alpha (CAMK2A), beta (CAMK2B), gamma (CAMK2G), and delta (CAMK2D). The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 12 subunits with two hexameric rings stacked one on top of t

Alternative Nomenclature

Calcium/calmodulin dependent protein kinase type 1G antibody

CaM kinase I gamma antibody

CaM kinase IG antibody

CaMK-like CREB kinase III antibody

Camk1g antibody

CLICK III antibody

VWS1 antibody