General Information

Product

cGKI Antibody

Description

Affinity Purified cGMP-dependent protein kinase 1 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 609-659 on human protein kinase G alpha subunit.

Accession #

NCBI: NP_001091982.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.64-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q13976

Overview

Serine/threonine protein kinase that acts as key mediator of the nitric oxide (NO)/cGMP signaling pathway. GMP binding activates PRKG1, which phosphorylates serines and threonines on many cellular proteins.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm

Expression

Primarily expressed in lung and placenta

Structure

Isoform alpha: parallel homodimer or heterodimer and also heterotetramer. Interacts directly with PPP1R12A. Non-covalent dimer of dimer of PRKG1-PRKG1 and PPP1R12A-PPP1R12A.

Alternative Nomenclature

cGK 1 antibody

cGKI alpha antibody

CGKI antibody

cGKI beta antibody

cGMP-dependent protein kinase 1 antibody

DKFZp686K042 antibody

FLJ36117 antibody

KGPB antibody

MGC71944 antibody

pkg antibody

PRKG1 antibody

PRKGR1A antibody

PRKGR1B antibody