General Information

Product

NTAL Antibody

Description

Affinity Purified Linker for activation of T-cells family member 2Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Immunogen

Synthetic peptide taken within amino acid region 40-90 on LAT2 protein.

Accession #

NCBI: NP_115852

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.54-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q9GZY6

Overview

Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells.

Molecular Function

SH2 domain binding

Subcellular Location

Cell membrane; Single-pass type III membrane protein

Expression

Highly expressed in spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. Also expressed in placenta, lung, pancreas and small intestine. Present in B-cells, NK cells and monocytes. Absent from T-cells (at protein level).

Structure

When phosphorylated, interacts with GRB2. May also interact with SOS1, GAB1 and CBL.

Alternative Nomenclature

HSPC046 antibody

LAB antibody

LAT2 antibody

Linker for activation of B cells antibody

Membrane associated adapter molecule antibody

Non T cell activation linker antibody

WBSCR 5 antibody

Wbscr15 antibody