General Information

Product

BTK Antibody

Description

Affinity Purified Bruton"s Tyrosine Kinase Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Pig, Rat

Immunogen

Synthetic peptide taken within amino acid region 550-650 on human BTK protein.

Accession #

NCBI: NP_000052.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.66 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

Q06187

Overview

Non-receptor tyrosine kinase invovled in B lymphocyte development.

Molecular Function

Kinase; Transferase; Tyrosine-protein Kinase

Subcellular Location

Cytoplasm; Cell Membrane; Peripheral membrane: Nucleus. In steady state BTK is predominantly cytosolic.

Expression

B-lymphocytes

Structure

PH domain mediates binding to inositol polyphosphate and phosphoinositides, leading to its targeting with plasma membrane. Extended in the BTK kinase family by a region designated Tec homology domain, which has roughly 80 residues preceding SH3 domain.

Alternative Nomenclature

Agammaglobulinaemia tyrosine kinase antibody

AGMX 1 antibody

AT antibody

ATK antibody

B cell progenitor kinase antibody

BPK antibody

Bruton tyrosine kinase antibody

Btk antibody

IMD1 antibody

PSCTK 1 antibody

Tyrosine protein kinase BTK antibody

XLA antibody

Agammaglobulinaemia tyrosine kinase antibody

AGMX 1 antibody

AT antibody

ATK antibody

B cell progenitor kinase antibody

BPK antibody

Bruton tyrosine kinase antibody

Btk antibody

IMD1 antibody

PSCTK 1 antibody

Tyrosine protein kinase BTK antibody

XLA antibody