General Information

Product

MAPK4 Antibody

Description

Affinity Purified Mitogen-activated protein kinase 4 Antibody

Verified Applications

ELISA, IP, WB

Host

Chicken

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 500-550 on human Mitogen-activated protein kinase 4.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P31152

Overview

Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle.

Molecular Function

Kinase, Serine/threonine-protein kinase, Transferase

Subcellular Location

Cytoplasm, Nucleus

Expression

High expression in heart and brain.

Structure

Homodimer. Heterodimer with ERK3/MAPK6. Interacts with (via FRIEDE motif) MAPKAPK5.

Alternative Nomenclature

ERK-4 antibody Extracellular signal-regulated kinase 4 antibodyMAP kinase 4 antibodyMAP kinase isoform p63 antibody

MAPK4 antibody

p63 MAPK antibody

PRKM4 antibodyProtein kinase, mitogen-activated, 4 antibodyProtein-tyrosine kinase ERK3-related antibodyRMNK2 antibody