General Information

Product

CD47 Antibody

Description

Affinity Purified Leukocyte surface antigen CD47 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse

Predicted:Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on human CD47 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q08722

Overview

Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus. Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

Molecular Function

Thrombospondin receptor activity; Cell adhesion

Subcellular Location

Cell membrane, Membrane

Expression

Very broadly distributed on normal adult tissues, as well as ovarian tumors, being especially abundant in some epithelia and the brain.

Structure

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative Nomenclature

Antigen identified by monoclonal antibody 1D8 antibody

Antigenic surface determinant protein OA3 antibody

CD47 antigen (Rh-related antigen, integrin-associated signal transducer) antibody

CD47 glycoprotein antibody

CD47 molecule antibody

IAP antibody

Integrin Associated Protein antibody

Integrin associated signal transducer antibody

Leukocyte surface antigen CD47 antibody

MER6 antibody

OA3 antibody

Protein MER6 antibody

Rh related antigen antibody