General Information

Product

TIA1 Antibody Affinity Purified

Description

Affinity Purified Nucleolysin TIA-1 isoform p40 Antibody

Verified Applications

CM, ELISA, ICC, IF, IHC, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 50-100 on human TIA1 protein.

Accession #

GenBank: BAD92448.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:50

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:50

Immunofluorescence

1:50

Immunohistochemistry

1:50

Western Blot

1:500

Protein

Uniprot #

P31483

Overview

Involved in alternative pre-RNA splicing and regulation of mRNA translation by binding to AU-rich elements (AREs) located in mRNA 3" untranslated regions (3" UTRs). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis.

Molecular Function

AU-rich element binding, nucleotide binding, poly(A) binding, poly (A) RNA binding

Subcellular Location

Cytoplasmic granule, nucleus. (Note: accumulates in cytoplasmic stress granules following cellular damage

Alternative Nomenclature

Cytotoxic granule associated RNA binding protein 1 antibody

Nucleolysin TIA 1 isoform p40 antibody

p40 TIA 1 antibody

p40-TIA-1 (containing p15-TIA-1) antibody

RNA binding protein TIA 1 antibody

T-cell-restricted intracellular antigen-1 antibody

TIA 1 cytotoxic granule associated RNA binding protein antibody

TIA1 cytotoxic granule associated RNA binding protein like 1 antibody

TIA1 protein antibody

TIAL1 antibody

TIAR antibody