General Information

Product

TMEM16A Antibody

Description

Affinity Purified Transmembrane protein 16A Antibody N-epitope

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region on 70-120 on mouse Transmembrane Protein 16A.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q8BHY3

Overview

Calcium-activated chloride channel (CaCC) which plays an important role in transepithelial anion transport and smooth muscle contraction. Required for the normal functioning of the interstitial cells of Cajal (ICCs) which generate electrical pacemaker activity in gastrointestinal smooth muscles. Acts as a major contributor to basal and stimulated chloride conductance in airway epithelial cells and plays an important role in tracheal cartilage development.

Molecular Function

Chloride channel, Developmental protein, Ion channel

Subcellular Location

Cell membrane; Multi-pass membrane protein, Cytoplasm

Expression

Highly expressed in pulmonary bronchiole epithelial cells, pancreatic and submandibular gland acinar cells, kidney proximal tubule, all retinal cell layers, most sensory cells of dorsal root ganglia, Leydig cells and spermatocytes (at protein level). Expressed at high levels in the thyroid gland and gastrointestinal muscles.

Structure

Homodimer. Interacts with CFTR.

Alternative Nomenclature

ANO 1 antibody

Anoctamin 1 antibody

Anoctamin 1 calcium activated chloride channel antibody

Ca2+ activated Cl- channel antibody

Discovered on gastrointestinal stromal tumors protein 1 antibody

DOG 1 antibody

Membrane protein antibody

Oral cancer overexpressed protein 2 antibody

ORAOV 2 antibody

TAOS2 antibody

Transmembrane protein 16A antibody

Tumor-amplified and overexpressed sequence 2 antibody