General Information

Product

PD-L1 Antibody

Description

Affinity Purified Programmed cell death 1 ligand 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey

Predicted:Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid reigon 80-130 on human Progammed cell death 1 ligand 1 protein.

Accession #

NCBI: NP_054862

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Purification Method

Immobilized antigen affinity chromatography

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q9NZQ7

Overview

Involved in the costimulatory signal, essential for T-cell proliferation and production of IL10 and IFNG, in an IL2-dependent and a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation and cytokine production.

Molecular Function

Receptor

Subcellular Location

Isoform 1 : Cell membrane; Single-pass type I membrane protein

Isoform 2 : Endomembrane system; Single-pass type I membrane protein

Expression

Highly expressed in the heart, skeletal muscle, placenta and lung. Weakly expressed in the thymus, spleen, kidney and liver. Expressed on activated T- and B-cells, dendritic cells, keratinocytes and monocytes.

Structure

Belongs to the immunoglobulin superfamily. BTN/MOG family.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Alternative Nomenclature

B7 H antibody

B7 homolog 1 antibody

CD 274 antibody

PD L1 antibody

PDCD1 ligand 1 antibody

PDCD1L1 antibody

PDCD1LG1 antibody

PDL 1 antibody

Programmed death ligand 1 antibody

RGD1566211 antibody