General Information

Product

TRPV6 Antibody

Description

Affinity Purified Transient receptor potential cation channel, subfamily V, member 6Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken from the region within amino acids 700-732 of TRPV6 protein. The peptide was covalently modified to acheive desired antigenicity. Modified peptide was covalently coupled to a carrier protein by heterobifunctional cross linker for immunogen preparation.

Accession #

GenBank: EAW51899.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.67 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

UPI00000380EC

Overview

Calcium selective cation channel probably involved in Ca2+ uptake in various tissues, including Ca2+ reabsorption in intestine. The channel is activated by low internal calcium level, probably including intracellular calcium store depletion, and the current exhibits an inward rectification. Inactivation includes both, a rapid Ca2+-dependent and a slower Ca2+-calmodulin-dependent mechanism, the latter may be regulated by phosphorylation. In vitro, is slowly inhibited by Mg2+ in a voltage-independent manner. Heteromeric assembly with TRPV5 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating.

Molecular Function

Calcium channel activity; Calmodulin binding

Subcellular Location

Cell membrane; Multi-pass membrane protein

Expression

Abundantly expressed in pancreas and placenta, and to a much lesser extend in stomach and kidney. Not detected in intestine.

Structure

Homotetramer and probably heterotetramer with TRPV5. Interacts with TRPV5. Interacts with S100A10 and probably with the ANAX2-S100A10 heterotetramer. The interaction with S100A10 is required for the trafficking to the plasma membrane. Interacts with calmo

Alternative Nomenclature

ABPZF antibody

Alu binding protein with zinc finger domain antibody

Calcium channel CaT1 antibody

Calcium transport protein 1 antibody

CaT L antibody

CaT1 antibody

ecac antibody

ECaC2 antibody

Epithelial apical membrane calcium transporter/channel CaT1 antibody

Epithelial calcium channel 2 antibody

HSA277909 antibody

LP6728 antibody

NUDC antibody

Transient receptor potential cation channel subfamily V member 6 antibody

TrpV6 antibody

ZFAB antibody