General Information

Product

ABL1 Antibody

Description

Affinity Purified Tyrosine-protein kinase ABL1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 990-1130 of human Isoform IB of Tyorsine-protein kinase ABL1 protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P00519

Overview

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration.

Molecular Function

Kinase, Transferase, Tyrosine-protein kinase

Subcellular Location

Cytoplasm > cytoskeleton, Nucleus, Mitochondrion

Expression

Widely expressed.

Structure

Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. Contains 1 proteins kinase domain. Contains 1 SH2 domain. Contains 1 SH3 domain.

Alternative Nomenclature

Abelson murine leukemia viral oncogene homolog 1 antibodyAbelson tyrosine protein kinase 1 antibodyAbl 1 antibodyABL antibodyABL proto oncogene 1 non receptor tyrosine kinase antibodyABL1 antibody bcr/abl antibodyc abl oncogene 1 receptor tyrosine kinase antibodyJTK7 antibodyp150 antibodyProto oncogene tyrosine protein kinase ABL1 antibodyProto-oncogene c-Abl antibodyTyrosine-protein kinase ABL1 antibodyv abl Abelson murine leukemia viral oncogene homolog 1 antibodyv abl antibody