General Information

Product

ITPR2 Antibody

Description

Affinity Purified Inositol 1,4,5-triphosphate receptor type 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 100-150 on rat Inosital 1,4,5-triphosphate receptor type 2 protein.

Accession #

NCBI: NP_112308

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.66 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P29995

Overview

Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. This release is regulated by cAMP both dependently and independently of PKA.

Molecular Function

Calcium ion binding; inositol 1,4,5-triphosphate binding; cellular response to hypoxia; Transport

Subcellular Location

Endoplasmic reticulum membrane; Multi-pass membrane protein

Expression

Isoform Short is found in skeletal muscle and heart.

Structure

The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region.

Alternative Nomenclature

4 antibody

5-trisphosphate receptor antibody

Inositol 1 4 5 trisphosphate receptor type 2 antibody

InsP3R2 antibody

IP3 R2 antibody

IP3 receptor antibody

IP3 receptor isoform 2 antibody

IP3R 2 antibody

ITPR 2 antibody

Type 2 inositol 1 4 5 trisphosphate receptor antibody

Type 2 inositol 1 antibody

Type 2 InsP3 receptor antibody