General Information

Product

TLR7 Antibody Affinity Purified

Description

Affinity Purified Toll-like receptor 7 precursor Antibody

Verified Applications

ELISA, WB

Host

Rabbit

Species Cross Reactivity

Cat, Human, Mouse, Pig

Immunogen

Synthetic peptide taken within amino acid region 175-225 on human TLR7 protein.

Accession #

NCBI: NP_057646.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.65-0.72 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:20,000

ELISA

1:20,000

Western Blot

1:500

Protein

Uniprot #

Q9NYK1

Overview

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR7 is a nucleotide-sensing TLR which is activated by single-stranded RNA. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).

Molecular Function

Receptor, double-stranded RNA bindng, single-stranded RNA binding

Subcellular Location

Endoplasmic reticulum membrane; Single-pass type 1 membrane protein, Endosome, Lysosome, Cytoplasmic vesicle

Expression

Detected in brain, placenta, spleen, stomach, small intestine, lung and in plasmacytoid pre-dendritic cells.

Structure

Interacts with MYD88 via their respective TIR domains. Interacts with UNC93B1 (By similarity).

Alternative Nomenclature

PRO285 antibody

TLR 7 antibody

Toll like receptor 7 antibody

UNQ248 antibody