General Information

Product

EpCAM Antibody

Description

Affinity Purified Tumor-associated Calcium signal transducer 1Antibody C-epitope

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Synthetic peptide taken within amino acid region 215-265on human Tumor-associated calcium signal transducer 1 protein.

Accession #

GenBank: EAX00219.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.78 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

C-epitope

Storage

-20⁰C for long term storage

Application Protocol

DOT Blot

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

UPI0000EE24A7

Overview

May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.

Molecular Function

Tumor antigen

Subcellular Location

Cell junction, Cell membrane, Membrane, Tight junction

Expression

Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC"s differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.

Structure

Belongs to EPCAM family. Contains 1 thryoglobulin type-1 domain.

Alternative Nomenclature

17 1A antibody

323/A3 antibody

Adenocarcinoma associated antigen antibody

Antigen identified by monoclonal antibody AUA1 antibody

CD326 antibody

Cell surface glycoprotein Trop 1 antibody

Cell surface glycoprotein Trop 2 antibody

CO17 1A antibody

DIAR5 antibody

EGP antibody

EGP2 antibody

EGP314 antibody

EGP40 antibody

Ep CAM antibody

Epithelial cell adhesion molecule antibody

Epithelial glycoprotein 314 antibody

ESA antibody

GA733 1 antibody

gastrointestinal tumor-associated antigen 2, 35-KD glycoprotein antibody

HNPCC8 antibody

Human epithelial glycoprotein 2 antibody

KS 1/4 antigen antibody

KSA antibody

Lymphocyte antigen 74 antibody

M1S 1 antibody

M1S2 antibody

M4S1 antibody

Major gastrointestinal tumor associated protein GA733 2 antibody

Membrane component chromosome 4 surface marker (35kD glycoprotein) antibody

MIC18 antibody

MK 1 antibody

TACD1 antibody

TROP1 antibody

Tumor associated calcium signal transducer 1 antibody

Tumor associated calcium signal transducer 2 precursor antibody