General Information

Product

Nicotinic Acetylcholine Receptor alpha 7 Antibody

Description

Affinity Purified Neuronal acetylcholine receptor subunit alpha-7 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Rat

Immunogen

Synthetic peptide corresponding to exon 5 of alpha 7-2 nAChRs protein.

Accession #

GenBank: XP_008757720

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.75-0.95 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:250

Protein

Uniprot #

Q05941

Overview

After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is blocked by alpha-bungarotoxin.

Molecular Function

Ion channel, Ligand-gated ion channel, Receptor

Subcellular Location

Cell junction › synapse › postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Structure

Homopentamer. Interacts with RIC3; which is required for proper folding and assembly.

Alternative Nomenclature

7nAChR antibody

A7 nicotinic acetylcholine receptor antibody

alpha-7 subunit antibody

AChR antibody

Acra7 antibody

Alpha 7 neuronal nicotinic acetylcholine receptor antibody

Alpha7 antibody

Alpha7 nicotinic receptor antibody

Cholinergic receptor nicotinic alpha 7 antibody

CHRNA7 antibody

CHRNA7-2 antibody

NACHRA 7 antibody

Neuronal acetylcholine receptor protein alpha 7 chain precursor antibody

Nicotinic acetylcholine alpha 7 subunit antibody

Schizophrenia neurophysiologic defect candidate antibody