General Information

Product

Mitofusin 2 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 543-593 on human Mitofusin 2 protein.

Accession #

NCBI: NP_055689

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.6 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunohistochemistry

1:100

Western Blot

1:500

Protein

Uniprot #

O95140

Overview

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression induces the formation of mitochondrial networks. Plays an important role in the regulation of vascular smooth muscle cell proliferation. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). Is required for PARK2 recruitment to dysfunctional mitochondria. Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress. Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions.

Molecular Function

Hydrolase; GTP-binding, Nucleotide binding

Subcellular Location

Mitochondrion outer membrane; Multi-pass membrane protein

Expression

Ubiquitous; expressed at low level. Highly expressed in heart and kidney.

Structure

Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA famil. Mitofusin subfamily. Contains 1 dynamin-type G (guanine nucleotide-binding) domain.

Alternative Nomenclature

CMT2A antibodyCMT2A2 antibodyCPRP 1 antibody EC 3.6.5.- antibodyFzo antibodyHSG antibodyhyperplasia suppressor gene antibodyHypertension related protein 1 antibodyKIAA0214 antibodyMARF antibodyMFN 2 antibody

Mitochondrial assembly regulatory factor antibodyMitofusin-2 antibody

Transmembrane GTPase MFN2 antibody