General Information

Product

ORP150 Antibody

Description

Affinity Purified Hypoxia up regulated 1 Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Rat

Immunogen

Synthetic peptide taken within amino acid region 950-999 on human Hypoxia up regulated 1.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9Y4L1

Overview

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Molecular Function

ATP binding; chaperone binding

Subcellular Location

Endoplasmic reticulum lumen

Expression

Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.

Structure

Part of a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Belongs to the heat shock protein 70 family.

Alternative Nomenclature

150 kDa oxygen regulated protein antibody

170 kDa glucose regulated protein antibody

DKFZp686N08236 antibody

FLJ94899 antibody

FLJ97572 antibody

glucose regulated protein 170 antibody

Grp 170 antibody

Grp170 antibody

HSP 12A antibody

HSP12A antibody

Hyou1 antibody

Hypoxia up regulated 1 antibody

Orp 150 antibody

Orp150 antibody

oxygen regulated protein (150kD) antibody