General Information

Product

p63 Antibody

Description

Affinity Purified Tumor protein 63 isoform 6 Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1-100 on human p63 protein.

Accession #

NCBI: NP_001108454

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.59-0.63 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

Q9H3D4

Overview

Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.

Molecular Function

Activator, Developmental protein, chromatin binding

Subcellular Location

Nucleus

Expression

Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type isoforms. Isoform 10 is predominantly expressed in skin squamous cell carcinomas, but not in normal skin tissues.

Structure

Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity. Isoforms Alpha and Gamma interact with HIPK2. Interacts with SSRP1, leading to stimulate coactivator activity. Isoform 1 and isoform 2 interact with WWP1. Interacts with PDS5A. Isoform 5 (via activation domain) interacts with NOC2L.

Alternative Nomenclature

AIS antibody

Amplified in squamous cell carcinoma antibody

B(p51A) antibody

B(p51B) antibody

Chronic ulcerative stomatitis protein antibody

CUSP antibody

DN p63 alpha 1 antibody

EEC3 antibody

Keratinocyte transcription factor antibody

KET antibody

LMS antibody

MGC115972 antibody

MGC192897 antibody

NBP antibody

OFC8 antibody

p40 antibody

p51 antibody

P51/P63 antibody

p53CP antibody

p63 antibody

P73 antibody

p73H antibody

p73L antibody

RHS antibody

SHFM4 antibody

TAp63alpha antibody

TP53CP antibody

TP53L antibody

TP63 antibody

TP73 antibody

Transformation related protein 63 antibody

Trp53rp1 antibody

Trp63 antibody

Tumor protein 63 antibody

Tumor protein p53-competing protein antibody

Tumor protein p63 deltaN isoform delta antibody

Tumor protein p73 antibody