General Information

Product

FXIIIA Antibody

Description

Affinity Purified Blood coagulation factor XIII a subunit Antibody Multi-epitope

Verified Applications

CM, ELISA, ICC, IHC, IF, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

Multi-epitope synthetic peptides were used: amino acid range 1-50 and 700-732. A mixture of synthetic peptides used for FXIIIA-101AP and FXIIIA-112AP.

Accession #

GenBank: AAA52415.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.55-0.75 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:10,000

ELISA

1:10,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

P00488

Overview

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Molecular Function

Metal ion binding; Protein-glutamine gamma-glutamyltransferase activity

Subcellular Location

Cytoplasm. Secreted

Structure

Tetramer of two A chains and two B chains.

Alternative Nomenclature

Coagulation factor XIII A chain antibody

F13A antibody

Factor XIIIA antibody

Fibrin stabilizing factor, A subunit antibody

Fibrinoligase antibody

FSF, A subunit antibody

TGase antibody

Transglutaminase A chain antibody

Transglutaminase. plasma antibody