General Information

Product

BST2 Antibody

Description

Affinity Purified Bonemarrow stromal antigen 2 Antibody N-epitope

Verified Applications

ELISA, CM, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human

Immunogen

N-epitope Synthetic peptide taken within amino acid region 1-50 on human Bonemarrow stromal antigen 2 protein.

Accession #

GenBank: BAD96844

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.62 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Determinant

N-epitope

Storage

-20⁰C for long term storage

Application Protocol

Confocal Microscopy

1:200

DB

1:2,000

ELISA

1:2,000

Immunocytochemistry

1:200

Immunofluorescence

1:200

Immunohistochemistry

1:200

Immunoprecipitation

1:200

Western Blot

1:500-1:1,000

Protein

Uniprot #

Q10589

Overview

IFN-induced antiviral host restriction factor which efficiently blocks the release of diverse mammalian enveloped viruses by directly tethering nascent virions to the membranes of infected cells.

Molecular Function

Antiviral defense; B-cell activation; Immunity; Innate immunity

Subcellular Location

Gogli apparatus, trans-golgi network; Cell membrane, Single-pass type II membrane protein. Lipid anchor, GPI anchor; Late endosome; Membrane raft; Cytoplasm; Apical cell membrane

Expression

Liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal msucle and brain. Overexpressed in multiple myeloma cells. B-cells, T-cells, monocytes, NK cells and dendritic cells. Induced by type I interforns. Down regulated by viral antagonistic factors.

Structure

Parallel homodimer; disulfide linked. Cytoplasmic domain interacts with ARHGAP44 and MMP14.

Alternative Nomenclature

Bone marrow stromal antigen 2 antibody

Bone marrow stromal cell antigen 2 antibody

BST 2 antibody

CD 317 antibody

CD317 antigen antibody

HM1.24 antigen antibody

NPC A 7 antibody

Tetherin antibody