General Information

Product

DCC Antibody

Description

Affinity Purified Netrin Receptor DCC Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 1330-1380 on rat DCC protein.

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-.70 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20°C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Western Blot

1:500

Protein

Uniprot #

P43146

Overview

Receptor for netrin required for axon guidance; may trigger signaling for axon repulsion; acts as a dependence receptor required for apoptosis induction; tumor suppressor gene.

Molecular Function

netrin receptor activity; transcription coactivator activity; transmembrane signaling receptor activity; Developmental protein

Subcellular Location

axon; cytosol; plasma membrane

Expression

Found in axons of the central and peripheral nervous system;differentiated cell types of the intestine

Structure

Belongs to the immunoglobulin superfamily. DCC family; Contains 6 fibronectin type-III domains; Contains 4 Ig-like C2-type (immunoglobulin-like) domains

Alternative Nomenclature

Colorectal cancer related chromosome sequence 18 antibody

CRC 18 antibody

CRCR 1 antibody

DCC antibody

Deleted in colorectal cancer protein antibody

Immunoglobulin superfamily DCC subclass member 1 antibody

Netrin receptor DCC antibody

Tumor suppressor protein DCC antibody