General Information

Product

Aquaporin 4 Antibody

Verified Applications

ELISA, ICC, IF, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Bovine, Human, Sheep, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 300-323 on rat Aquaporin 4 protein.

Accession #

NCBI: NP_001641

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.50-0.62 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunocytochemistry

1:100

Immunofluorescence

1:100

Immunohistochemistry

1:100

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P55087

Overview

Forms water specific channel. Osmoreceptor which regulates water balance and mediates water flow within CNS.

Molecular Function

Transport

Subcellular Location

Membrane; Multi-pass protein

Expression

Abundant in mature brain but only weakly detectable in eye, kidney, intestine, and lung.

Structure

Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA).

Alternative Nomenclature

AQP 4 antibody

Aquaporin type 4 antibody

Aquaporin-4 antibody

HMIWC2 antibody

Mercurial insensitive water channel antibody

MGC22454 antibody

MIWC antibody

WCH 4 antibody