General Information

Product

5HT1A Receptor Antibody

Description

Affinity Purified 5 Hydroxytryptamine 1A receptor Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide corresponding to amino acids within region 200-250 on rat 5-hydroxytryptamine receptor 1A protein.

Accession #

NCBI: NP_036717

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:50,000

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P19327

Overview

G-protein coupled receptor for serotonin (5-hydroxytryptamine). Functions as a receptor for various drugs which cause conformational change upon ligand binding that triggers signaling via guanine nucleo-tide binding proteins and modulation of down-stream effectors like adenylate cyclase. Inhibits adenylate cyclase activity and activates phosphatidylinositol-calcium second messenger system that regulates release of intracellular Calcium ions.

Molecular Function

serotonin receptor activity

Subcellular Location

Cell membrane; Multi-pass protein

Expression

Lymph nodes, thymus, spleen, activated T-cells

Structure

Heterodimer

Alternative Nomenclature

ADRBRL1 antibody

G 21 antibody

Gpcr18 antibody

Guanine nucleotide binding regulatory protein-coupled receptor antibody

HTR1A antibody

PFMCD antibody