General Information

Product

5HT1B Receptor Antibody

Description

Affinity Purified 5 Hydroxytryptamine 1B receptor Antibody

Verified Applications

ELISA, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 160-260 on rat 5HT1B

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5-1.5 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:50,000

ELISA

1:50,000

Immunoprecipitation

1:200

Western Blot

1:2,500-1:5,000

Protein

Uniprot #

P28334

Overview

G-protein coupled receptor for serotonin (5-hydroxytryptamine). Functions as a receptor for various drugs which cause conformational change upon ligand binding that triggers signaling via guanine nucleo-tide binding proteins and modulation of down-stream effectors like adenylate cyclase. Inhibits adenylate cyclase activity and activates phosphatidylinositol-calcium second messenger system that regulates release of intracellular Calcium ions.

Molecular Function

Drug binding, serotonin receptor activity, serotonin binding

Subcellular Location

Cell membrane; Multi-pass protein

Structure

Homodimer. Heterodimer with HTR1D

Alternative Nomenclature

HTR1DB antibody

S12 antibody

Serotonin 1D beta receptor antibody