General Information

Product

FPR1 Antibody

Description

Affinity Purified N-formyl peptide receptor Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Human, Monkey, Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 150-200 on N-formyl peptide receptor.

Accession #

GenBank: AAA16863.1

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.5 µg/µl in antibody stabilization buffer

Immunoglobulin

IgG

Form

Affinity Purified

Storage

-20⁰C for long term storage

Application Protocol

ELISA

1:10,000

Immunoprecipitation

1:200

Western Blot

1:500

Protein

Uniprot #

P21462

Overview

High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456).

Molecular Function

N-formyl peptide receptor activity; Receptor activity

Subcellular Location

Cell membrane; Multi-pass membrane

Structure

Belongs to the G-protein coupled receptor 1 family.

Alternative Nomenclature

fMet Leu Phe receptor antibody

FMLP antibody

FMLPR antibody

Formyl peptide receptor 1 antibody

FPR 1 antibody

FPR receptor antibody

N formyl peptide chemoattractant receptor antibody

N formyl peptide receptor antibody