General Information

Product

C6orf150 Antibody

Description

Affinity Purified Cyclic GMP-AMP synthase Antibody

Verified Applications

ELISA, IHC, IP, WB

Host

Rabbit

Species Cross Reactivity

Mouse, Rat

Immunogen

Synthetic peptide taken within amino acid region 450-500 on mouse cGAS protein.

Accession #

NCBI: NP_775562

Physical Properties

Quantity

100 µg

Volume

200 µl

Concentration

0.60 µg/µl in antibody stabilization buffer

Form

Affinity Purified

Clonality

Polyclonal

Storage

-20⁰C for long term storage

Application Protocol

DB

1:10,000

ELISA

1:10,000

Immunoprecipitation

1:150

Western Blot

1:500

Protein

Uniprot #

Q8C6L5

Overview

Catalyzes the formation of cyclic GMP-AMP from ATP and GTP. Has antiviral activity through acting as a cystolic DNA senser.

Molecular Function

Nucleotidyltransferase; ATP binding; DNA binding

Subcellular Location

Cytoplasm; Cytosol

Expression

Is expressed in the monocytic cell line THP1 by type 1 Interferons

Structure

Monomer when in absence of DNA. Homodimer when bound to DNA.

Alternative Nomenclature

C6orf150 antibody

cGAMP synthase antibody

cGAS antibody

Chromosome 6 open reading frame 150 antibody

Cyclic GMP-AMP synthase antibody

h-cGAS antibody

Hypothetical protein LOC115004 antibody

Mab 21 domain containing 1 antibody

MB21D1 antibody

protein MB21D1 antibody

Uncharacterized protein C6orf150 antibody